HCG use after recon

[skip2967]

Got a 5000IU vial of HCG.Another brand was substituted from what i ordered. Packaging says inject IM only and discard any left over solution once reconstituted. HCG is HCG so if most brands say storing in fridge is ok then all HCG should be ok stored right? Does anyone see any issue with being stored in fridge and used within a week? And also being shot sub-q? thanks for any input bros

[Action]

Originally Posted by skip2967

Got a 5000IU vial of HCG.Another brand was substituted from what i ordered. Packaging says inject IM only and discard any left over solution once reconstituted. HCG is HCG so if most brands say storing in fridge is ok then all HCG should be ok stored right? Does anyone see any issue with being stored in fridge and used within a week? And also being shot sub-q? thanks for any input bros

That's fine. As long as it's used within about a 30 day period.

You can inject HCG sub-q, but it might take a little longer for absorption as opposed to IM. Some reason why you're not shooting IM?

[Replicator]

Originally Posted by skip2967

Got a 5000IU vial of HCG.Another brand was substituted from what i ordered. Packaging says inject IM only and discard any left over solution once reconstituted. HCG is HCG so if most brands say storing in fridge is ok then all HCG should be ok stored right? Does anyone see any issue with being stored in fridge and used within a week? And also being shot sub-q? thanks for any input bros

Yes all HCG should be the same , please see red highlighted below
REP

DESCRIPTION
Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human
placenta, is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially
identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone
(LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human
thyroid-stimulating hormone (TSH). The beta sub-units of these hormones differ in amino
acid sequence.
PREGNYL® (chorionic gonadotropin for injection, USP) is a highly purified pyrogen-free
preparation obtained from the urine of pregnant females. It is standardized by a biological
assay procedure. It is available for intramuscular injection in multiple dose vials containing
10,000USPUnits of sterile dried powderwith 5mgmonobasic sodiumphosphate and 4.4mg
dibasic sodium phosphate. If required, pH is adjusted with sodium hydroxide and/or phosphoric
acid. Each package also contains a 10 mL vial of solvent containing: water for injection
with 0.56%sodiumchloride and 0.9%BENZYL ALCOHOL,WHICH IS NOT FOR USE IN
NEWBORNS. If required, pH is adjusted with sodium hydroxide and/or hydrochloric acid.
CLINICAL PHARMACOLOGY
The action of HCG is virtually identical to that of pituitary LH, although HCG appears to have
a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones
by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens and the
corpus luteum of the ovary to produce progesterone.
Androgen stimulation in the male leads to the development of secondary sex characteristics
and may stimulate testicular descent when no anatomical impediment to descent is
present. This descent is usually reversible when HCG is discontinued. During the normal
menstrual cycle, LH participates with FSH in the development andmaturation of the normal
ovarian follicle, and the mid-cycle LH surge triggers ovulation. HCG can substitute for LH
in this function.
During a normal pregnancy, HCG secreted by the placentamaintains the corpus luteumafter
LH secretion decreases, supporting continued secretion of estrogen and progesterone and
preventingmenstruation. HCG HAS NO KNOWN EFFECT ON FATMOBILIZATION, APPETITE
OR SENSE OF HUNGER, OR BODY FAT DISTRIBUTION.
INDICATIONS AND USAGE
HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE
TREATMENT OF OBESITY. THERE IS NO SUBSTANTIAL EVIDENCE THAT IT INCREASES
WEIGHT LOSS BEYOND THAT RESULTING FROMCALORIC RESTRICTION, THAT IT CAUSES
A MORE ATTRACTIVE OR “NORMAL” DISTRIBUTION OF FAT, OR THAT IT DECREASES
THE HUNGER AND DISCOMFORT ASSOCIATED WITH CALORIE-RESTRICTED DIETS.
1. Prepubertal cryptorchidismnot due to anatomical obstruction. In general, HCG is thought
to induce testicular descent in situations when descent would have occurred at puberty.
HCG thus may help predict whether or not orchiopexy will be needed in the future.
Although, in some cases, descent following HCG administration is permanent, in most
cases, the response is temporary. Therapy is usually instituted in children between the
ages of 4 and 9.
2. Selected cases of hypogonadotropic hypogonadism(hypogonadismsecondary to a pituitary
deficiency) in males.
3. Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the
cause of anovulation is secondary and not due to primary ovarian failure, and who has
been appropriately pretreated with human menotropins.
CONTRAINDICATIONS
Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior
allergic reaction to HCG.
WARNINGS
HCG should be used in conjunction with human menopausal gonadotropins only by physicians
experienced with infertility problems who are familiarwith the criteria for patient selection,
contraindications,warnings, precautions, and adverse reactions described in the package
insert for menotropins.
The principal serious adverse reactions during this use are: (1) Ovarian hyperstimulation, a
syndrome of sudden ovarian enlargement, ascites with or without pain, and/or pleural effusion,
(2) Rupture of ovarian cysts with resultant hemoperitoneum, (3) Multiple births, and
(4) Arterial thromboembolism.
PRECAUTIONS
General
Since androgens may cause fluid retention, HCG should be used with caution in patients
with cardiac or renal disease, epilepsy, migraine, or asthma.
Pediatric Use
Induction of androgen secretion by HCG may induce precocious puberty in pediatric
patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious
puberty occur.
Geriatric Use
Clinical studies of PREGNYL® (chorionic gonadotropin for injection, USP) did not include
subjects aged 65 and over.
ADVERSE REACTIONS
Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia,
pain at the site of injection.
DOSAGE AND ADMINISTRATION
For intramuscular use only. The dosage regimen employed in any particular casewill depend
upon the indication for the use, the age and weight of the patient, and the physician’s preference.
The following regimens have been advocated by various authorities:
Prepubertal cryptorchidismnot due to anatomical obstruction. Therapy is usually instituted
in children between the ages of 4 and 9.
1. 4,000 USP Units three times weekly for three weeks.
2. 5,000 USP Units every second day for four injections.
3. 15 injections for 500 to 1,000 USP Units over a period of six weeks.
4. 500 USP Units three times weekly for four to six weeks. If this course of treatment is not
successful, another series is begun onemonth later, giving 1,000 USP Units per injection.
Selected cases of hypogonadotropic hypogonadism in males.
1. 500 to 1,000 USP Units three times a week for three weeks, followed by the same dose
twice a week for three weeks.
2. 4,000 USP Units three times weekly for six to nine months, following which the dosage
may be reduced to 2,000 USP Units three times weekly for an additional three months.
Induction of ovulation and pregnancy in the anovulatory, infertilewoman in whomthe cause
of anovulation is secondary and not due to primary ovarian failure and who has been appropriately
pretreated with humanmenotropins. (See prescribing information formenotropins
for dosage and administration for that drug product.)
5,000 to 10,000 USP Units one day following the last dose of menotropins. (A dosage of
10,000 USP Units is recommended in the labeling for menotropins.)
Directions for Reconstitution
Two-vial package:Withdrawsterile air fromlyophilized vial and inject into diluent vial. Remove
1–10 mL from diluent and add to lyophilized vial; agitate gently until powder is completely
dissolved in solution.
Parenteral drug products should be inspected visually for particulate matter and discoloration
prior to administration, whenever solution and container permit.
IMPORTANT: USE COMPLETELY AFTER RECONSTITUTION. RECONSTITUTED SOLUTION
IS STABLE FOR 60 DAYS WHEN REFRIGERATED.
HOW SUPPLIED
Two-vial package containing:
1-10mL lyophilizedmultiple dose vial containing: 10,000 USP Units chorionic gonadotropin
per vial, NDC 0052-0315-10.
1-10 mL vial of solvent containing: water for injection with sodium chloride 0.56% and
benzyl alcohol 0.9%, NDC 0052-0325-10.
When reconstituted, each 10 mL vial contains:
Chorionic gonadotropin 10,000 USP Units
Monobasic sodium phosphate 5 mg
Dibasic sodium phosphate 4.4 mg
Sodium chloride 0.56%
Benzyl alcohol 0.9%
If required pH adjusted with sodium hydroxide and/or phosphoric acid.
Storage: Store at 15–30°C (59–86°F). Reconstituted solution is stable for 60 days when refrigerated.
Manufactured for Organon USA Inc.
Roseland, NJ 07068
by Baxter Pharmaceutical Solutions LLC
Bloomington, IN 47403
© 2006 Organon USA Inc. PRE-75899 8/06 20-8.5x11

[skip2967]

thanks for the input gents. i figured it was fine but just odd how the paperwork with it said discard immediatley after recon.

And Action i just personally prefer sub-q but if IM absorbs faster ill do that. plus im running cjc1295/ghrp-6 so it would all be sub-q administration. I shot the first dose IM so no issue.

[chiselmeat]

I have read that sub q absorbs as well as IM. I believe sub q is most often the way HCG is taken.. I know the HCG wheight loss program set out by Dr. Simmons called for sub q. Also most peptides are sub q, although it is hard to sub q your biceps, as with IGF-1 lr3, with one hand in which case I go IM.

[masswithclass]

I have always sub q

[Action]

Some go IM, some go sub-q. I have personally always gone IM.

[Action]

Originally Posted by chiselmeat

I have read that sub q absorbs as well as IM. I believe sub q is most often the way HCG is taken.. I know the HCG wheight loss program set out by Dr. Simmons called for sub q.

Good points. Sub q can allow for a slower, sustained and more constant release. IM may be a faster absorption rate depending on blood flow at the injection site. So, it all depends on the injection area, whether it's IM or sub-q, on the rate of best absorption.

[Replicator]

Originally Posted by masswithclass

I have always sub q

me too
Rep

[Pushin50]

Hey Replicator, just got in my EC-HCG. Says on my bottle "Store protected from light 2-15 C". Does this mean once reconstituted? Can I store them at room temp until then?

[Replicator]

Originally Posted by Pushin50

Hey Replicator, just got in my EC-HCG. Says on my bottle "Store protected from light 2-15 C". Does this mean once reconstituted? Can I store them at room temp until then?

yes you can store at room temp in a drawer out of the light. I just store mine in my bedroom drawer then in the fridge after reconstitution. and always best to use bac water rather than the vile they give you with it. which will help better to prelong it for the 60 days after reconstitution

HOW TO MIX AND STORE HCG.

The water you need to reconstitute hCG is bacteriostatic water.
Calculating hCG:
There isn't a specific ratio of ml to IU. It depends on how you mix it. It's quite simple. If you dillute 5,000 IUs hCG with 5ml of bacwater, the end result is 1,000 IUs per ml. Divide the same 5,000 IUs with 10 ml and the end result is 500 IUs per ml. Therefore, a large part depends on the concentration of hCG per ampoule or vial.

Mixing hCG:
Items needed: bacteriostatic water (not the water/solvent that comes with the kit) and some 5ml empty sterile vials or some syringes/slin pins.
1) Open hcg/amp with powder
2) Use a syringe to pull out 1ml of Bac Water and put in amp with hCG
3) It will instantly dissolve
4) Then Use an empty 5ml vial (sterile and sealed) put 4ml of Bac water in the vial
5) Take syringe and ad the mixed hCG solution to the 5ml vial
6) Swirl gently and you have 5000IU's of hCG
7) Then draw 1ml (1000iu) and inject
8) put the rest in the refrigerator
9) Only use as much bac water as you need, too much may have a detrimental effect when the reconstituted hCG is stored.

•The reason your discarding the amp of solvent is because its made for a single use.
•The most common side affect associated with hCG is gynecomastia. The concurrent intake of Nolvadex with hCG prevents gynecomastia, prevents/minimizes leydig cell desensitization and continues the stimulation of pituitary LH once hCG has been discontinued.
•hCG will last up to 6 weeks if mixed with Bac water instead of the solvent it comes with.
•You can keep the mixed hCG in vials or syringes in the fridge till use.


REP

[Pushin50]

Thanks REP!