HCG official Information

[Supaman]

PREGNYLŪ

RA 2400 ZA S1 (ref 1.0).

SCHEDULING STATUS:
S4

PROPRIETARY NAME
(and dosage form):

PREGNYLŪ

PregnylŪ 1 500 IU powder for solution for injection, provided with Solvent for Pregnyl
PregnylŪ 5 000 IU powder for solution for injection, provided with Solvent for Pregnyl

COMPOSITION
PREGNYL contains 1 500 and 5 000 I.U. Chorionic Gonadotrophin per ampoule
Each 1 mL ampoule of Solvent for Pregnyl contains 0,9% m/v sodium chloride in water for injection

PHARMACOLOGICAL CLASSIFICATION
A/21.10/Trophic hormones

PHARMACOLOGICAL ACTION
Pharmacodynamics
Pregnyl contains human Chorionic Gonadotrophin (hCG) which has luteotrophic (LH) activity.
In the female Pregnyl substitutes the endogenous mid-cycle LH surge to induce the final phase of follicular maturation, leading to ovulation.
In the male Pregnyl stimulates Leydig cells to promote the production of testosterone.
Pharmacokinetics
Maximal plasma hCG levels will be reached in males approximately 6 and 16 hours after a single intramuscular or subcutaneous injection of hCG, respectively and in females after approximately 20 hours. HCG is approximately 80 per cent metabolized, predominantly in the kidneys. Intramuscular and subcutaneous administration of hCG were found to be bioequivalent regarding the extent of absorption and the apparent elimination half-lives of approximately 33 hours. On basis of the recommended dose regimens and elimination half-life, cumulation is not expected to occur.
Preclinical safety data
No particulars.

INDICATIONS
In the male:
- Hypogonadotrophic hypogonadism. Cases of idiopathic dysspermias have also shown a positive response to gonadotrophins.
- Delayed puberty associated with insufficient gonadotrophic pituitary function.
- Cryptorchidism, not due to anatomical obstruction.

CONTRA-INDICATIONS
- Hypersensitivity to human gonadotrophins or any of the substances of Pregnyl.
- Known or suspected androgen-dependent tumours, such as prostatic carcinoma or breast carcinoma in the male.
- Pregnancy and lactation: Pregnyl may be used for luteal phase support. It must not be used during lactation.

WARNINGS
In the male:
Treatment with hCG leads to increased androgen production. Therefore:
- Patients with latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions) should be warned and kept under close medical supervision, since aggravation or recurrence may occasionally be induced as a result of increased androgen production.
- hCG should be used cautiously in prepubertal boys to avoid premature epiphyseal closure or precocious sexual development. Skeletal maturation should be monitored regularly.
Interactions
Interaction with other medicaments and other forms of interaction:
No interactions of clinical relevance are known.

DOSAGE AND DIRECTIONS FOR USE
Dosage in the male:
Hypogonadotrophic hypogonadism: [Absent or decreased function of the male testis. It results from the absence of the gonadal stimulating pituitary hormones, FSH (follicle stimulating hormone) and LH (luteinizing hormone).]
1000-2000 I.U. Pregnyl, two to three times per week. If the main complaint is subfertility, additional doses of an FSH-containing preparation (75 I.U. FSH) daily or two to three times a week, may be given. This treatment should be continued for at least three months before any improvement in spermatogenesis can be expected. During this treatment testosterone replacement therapy should be suspended. Once achieved, the improvement may sometimes be maintained by hCG alone.
Delayed puberty
1500 I.U. two to three times a week for at least six months.
Cryptorchidism:
- under 2 years of age: 250 I.U. twice weekly for six weeks
- under 6 years of age: 500-1000 I.U. twice weekly for six weeks
- over 6 years of age: 1500 I.U. twice weekly for six weeks
If necessary, this treatment can be repeated.
See Warnings.

Method of administration:
After addition of the solvent to the freeze-dried substance, the reconstituted Pregnyl solution should be slowly administered intramuscularly or subcutaneously.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS
Reactions at the site of injection, such as bruising, pain, redness, swelling and itching, have been reported with the use of urinary gonadotrophin preparations. Occasionally allergic reactions have been reported, mostly manifesting as pain and/or rash at the injection site. In rare cases generalized rash or fever may occur.
In the male:
Water and sodium retention is occasionally seen after administration of high dosages; this is regarded as a result of excessive androgen production.
HCG treatment may sporadically cause gynaecomastia.

Effects on ability to drive and use machines:
As far as known this medicine has no influence on alertness and concentration.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
The acute toxicity of urinary gonadotrophin preparations has been shown to be very low. There are no symptoms of an acute parenteral overdose known in humans.

STORAGE INSTRUCTIONS
Store in a refrigerator between 2°-8°C. Protect from light. Keep out of reach of children.

REFERENCE NUMBERS
Pregnyl 1500 I.U. & Solvent for Pregnyl.: G 3202 (Act 101/1965)
Pregnyl 5000 I.U. & Solvent for Pregnyl: G 3203 (Act 101/1965)

NAME AND BUSINESS ADDRESS OF THE APPLICANT
Donmed Pharmaceuticals (Pty) Limited
Donmed House
Cambridge Place
cnr Kirkby & Oxford Roads
Bedfordview 2007

DATE OF PUBLICATION OF THE PACKAGE INSERT
4 November 2003

Under license of NV Organon, The Netherlands

RA 2400 ZA S1 (ref 1.0).

Updated on this site: March 2004
Source: Pharmaceutical Industry

[Supaman]

Taken from steroid.com:

HCG CYCLES
As regards HCGs use of Post-Cycle-Therapy (PCT), smaller and more frequent doses after a cycle of AAS would give the best results with the least amount of side effects. A dose of 250iu to 500iu everyday (ed) for 2 to 3 weeks is plenty and should very little from person to person (3). The Physicians Desk Reference recommends 500iu/day, as did the late, great, Dan Duchaine. The smaller doses are sufficient enough to begin reversal of testicular atrophy and used in conjunction with nolvadex, will help the already present problem of recovery without raising the levels of estrogen to high and increasing the risk of gynecomastia in the user. Lower doses of 250iu to 500iu also avoid the further risk of down regulating LH receptors in the testes. The old saying more is better definitely does not apply to the use of HCG. You dont want to finish PCT after using too much HCG only to find out your back at the beginning again. Your best bet is to start at 250iu or 500iu ed for 5 or 6 days, and if you dont notice anything happening (nuts dropping and getting bigger) up the dose slightly. Small doses like 500iu two days a week isnt going to cut it like some people think. The only thing small doses of HCG ay be useful (sublingually) for is reducing symptoms of benign prostatic hyperplasia (7). Yeah, thats right, you can probably reduce some symptoms of an enlarged prostate with the use of small doses of HCG.

As stated above the cycles of HCG should be in the 2 to 3 week range with a least one month off in between, you could stretch your cycle out to four weeks without any major concern if you are using lower doses. One should however take care when using HCG as prolonged use could repress the bodys natural production of gonadotropins permanently, but this is mostly just pure speculation as it does not have yet to be reported nor has there been a case of an overdose. To be on the safe side shorter cycles of HCG seem to be that of the norm. Most users cycle HCG near the end of a steroid cycle, you should start your HCG therapy on the last week of your cycle. For best results you should also run nolva while you run HCG as taking HCG by itself will do little to nothing and gyno even though rare may also flair up. Once the HCG cycle is finished you continue with your usual clomid or nolvadex (preferably the latter) for pct as it is more effective when used in conjunction HCG for pct. With an AAS cycle of 6 to 10 weeks HCG may not be necessary unless extreme doses of AAS were used or there is an existing problem of testicular atrophy or you are running a heavy oral only cycle. AAS cycles of 12 or more weeks should have HCG as a part of post cycle plan.

[dieselman2388]

I disagree with the part about cycles of 6-10 weeks not requiring hcg. I think if you wanna use AAS long term you better always use HCG.

[cookiedough]

I agree w/dieselman

[Supaman]

Originally Posted by dieselman2388

I disagree with the part about cycles of 6-10 weeks not requiring hcg. I think if you wanna use AAS long term you better always use HCG.

I agree. But this is besides the point.
I put up this information for reference and to show everyone that they shoudn't be afraid of high dosage of hcg, it was meant to be taken like that.
But if the low dose is working for you, more power to you, keep on doing what's working for you.

[seapro]

Originally Posted by Supaman

I agree. But this is besides the point.
I put up this information for reference and to show everyone that they shoudn't be afraid of high dosage of hcg, it was meant to be taken like that.
But if the low dose is working for you, more power to you, keep on doing what's working for you.

High dose came through for me, i dropped the nolv and just ran it with arom and my shit seems to be back together. knock on wood, i'm feeling this will work out as i already want to fuck other girls

[Supaman]

Originally Posted by seapro

High dose came through for me, i dropped the nolv and just ran it with arom and my shit seems to be back together. knock on wood, i'm feeling this will work out as i already want to fuck other girls

Dosage in the male:
Hypogonadotrophic hypogonadism: [Absent or decreased function of the male testis. It results from the absence of the gonadal stimulating pituitary hormones, FSH (follicle stimulating hormone) and LH (luteinizing hormone).]
1000-2000 I.U. Pregnyl, two to three times per week.

[Pushin50]

Thanks for the info Supaman! Going to go off cycle as soon as my HCG, Cloms an Nolvadex arrives, this post is going to help alot