Drug expiration dates

Got this from the net and thought I would share it...I have Anavar that's about a year past it's expiration date that I still haven't had a chance to use...Bottom line is that the use of expiration dates is clearly a marketing and financial ploy for drug companies to make their millions and billions of dollars and keep the money flowing out of peoples wallets...

Drug Expiration:

You add another small prescription bottle to that too crowded medicine cabinet, the bottles nudge each other out of place, some tumbling out and down the sink. A quick date-inventory finds half of them in varying dates of expiry: a month, 6 months, a year. Tsk, tsk, tsk . . . what a waste! . . . and you're swiping the "expired" prescription drugs, over-the-counters, vitamins and supplements to the trash.

What does the expiration date signify? Have the "expired" medications really lost potency? Do they really expire on the expiry dates? "Expired," do they become harmful?

The "expiry date" or "expiration date" does not indicate a point when a medication loses potency and is no longer effective or becomes harmful. It is simply a date "required by law" generally set at two to three years after the '"manufacture date" of new medicines, usually embossed or printed on the original packaging. For prescriptions filled by the pharmacist, it is usually dated a year after being dispensed from the original container.

Drug companies admit there are no real data and that since some drugs expire earlier or faster than others, some manufacturers make a calculated guess at shelf life, then cut that in half to avoid legal consequences.

Studies have been done to test the stability of drugs beyond the expiration date. Stored under reasonable conditions, many drugs retain 90% of their potency for at least five years after the label's expiration date; sometimes, longer.

The FDA studied more than 100 drugs. It found that 90 percent of both prescription and over-the-counter medicines were perfectly good to use even 15 years (!) after the expiration date.

The exceptions are insulin, liquid antibiotics and nitroglycerin.

And loss of potency does not translate to harmfulness. Other than a contested report associated with use of degraded tetracycline causing Fanconi's syndrome, there are virtually no reports of toxicity from outdated drugs. At most, they lose some potency.

Storing the medications in a cool place, such as a refrigerator, will help extend potency for many years. However, most impoverished Third World countries do not have the luxury of refrigeration or cool storage places, and stability studies need to be done for drugs in the environ of prolonged heat and humidity.

Is the expiry date a mere marketing ploy? A commercial ploy that tags obsolesence to still potent drugs? Easy math. . . billions of drugs are regularly trashed and dumped because of expiration dates. Worldwide, the amount is staggering. Manufacturers claim for "product integrity." Consumers cry "profit!"

And for sure, the dilemma of expiry dates will continue to be cause for concern. How long ago did it "expire?" How much have time, heat and humidity contributed to a decline in potency? In many impoverished settings of third world countries, patients don't have much of a choice. And when an "expired" drug works, it might have done so through its persisting potency, or through the powers of placebo or through a dose of tincture of time.

Some physicians feel comfortable doubling the time of use, from manufacture to expiration date.

In impoverished areas, where the choice is to treat wtih "expired" medications or NO treatment, the choice is a 'no-brainer.'

But if there is a choice, where potency is further brought to question because of weather and storage and cost not a problem, there are certain conditions where 100% absolute certainty of potency is preferable - for heart conditions, strokes, TIAs, and life-threatening infections. Aspirin potency may not be as important for the simple ache or headache as it would be in a TIA, stroke prevention or heart conditions. Antibiotic potency might not be as critical in the empiric treatment for suspected sinus infections as they might be for respiratory infections in the elderly and lung-compromised patients.

So, when the urgency of clinical situation dictates, or when the conditions of storage are of concern, together with length of time beyond expiry date - until technology can gadget up some time-and-cost-effective way of determining drug potency - for both over-the-counter and prescription pharmaceuticals, opt for the new bottle or the new prescription.

Thanks Action for the info,i always had ? in the back of my head about this,thanks for clearing that ? up!

Very Good Action, Thats good to know...

Damn! Guess I'll dig those prescriptions out of the garbage! Good info to know!

[powerman]

Just wanted to make a post in this thread so evryone has a chance to glance at it again . Very good info and ive had this argument with wife and motherinlaw countless times

[mike0286]

awsome...you probably just saved me money

[Sinjin]

I will tell you, knowing from being on some advisory boards for hospital pharmacies, that drug companies fight tooth and nail to get the shortest expiration date possible. It has almost nothing to do with chemistry !!!!!!!! It is lobbyists and bureaucracy. I dug up some local anesthetic for a minor procedure I had to do on my dog. Only ones I could find around the house was from 1989. So it was 20 years beyond the expiration date. No discoloration, used it....got the foxtail out, no yelping never moved after the injection.

Now some drugs do have a fixed life depending on their volatility chemically and their preservatives if any are used. Some like nitroglycerin are very sensitive to humidity. Meaning for heart--angina, once the bottle is opened the pills don't last long after that. However as long as they aren't opened, they'll last for years. Nitroprusside a rapid vasodilator in the hospital for rapid control of blood pressure or angina is very sensitive to light and is kept in a dark covered bag. Botox, once reconstituted only lasts about 10-14 days. Propofol a common anesthetic has proteins in it which are great media for bacterial growth and changes color rapidly so once opened after 24 hours it is history.

There are more but they are the exception. With AAS, if they are kept cool they should last years beyond exp. date.

HCG, GH unfortunately will not due to the chemical make up of the proteins. They are unstable.

[mike0286]

I heard of guys keeping their test etc. in the fridge (thought it was weird, but maybe I was wrong)....Good idea or just leave out like normal????