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Best IGF-1 LR3 post I have found

Anabolic Steroids Discuss Best IGF-1 LR3 post I have found in the Steroid forums; This was written by a guy who has researched this stuff for 13 years and followed the work of Dave ...

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Old 03-29-2010, 04:12 PM
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Default Best IGF-1 LR3 post I have found

This was written by a guy who has researched this stuff for 13 years and followed the work of Dave Palumbo and seems to be the best information out there on IGF-1 LR3. Leads me to the conclusion that 20mcg post workout bilateral injections would be best on workout days only. Anyway, Read up:


"What do we want? Bigger muscles. More muscle cells that we will later grow with exercise and gear. A pump? Fatloss? Yeah, right. You can get a pump with a good "pump" product for a quarter of the price of IGF-1. Fatloss? Clen/Alb and T3/T4 will give it to you again at a fraction of the price of IGF-1. More muscle cells, you can ONLY get with IGF-1 (and MGF too). Nothing else will give it to you and if you are using IGF-1 for anything else, you are misusing it. More muscle cells is CLEARLY the best use for IGF-1.

What does all this tell us?

It tells us that we should use IGF-1 to make more muscle cells. It's the only thing that can give it to us and more cells is more growth, which is our goal.

What does this tell us?

The localized effects are the best. Long R3 IGF-1 can float around your body and attach to anything that has IGF-1 receptors. The intestines is the place that has the MOST IGF-1 receptors and it also happens to have lots of blood flow. Injecting large amounts of Long R3 ENSURES that you are growing your intestines. Remember, more cells doesn't equal more size right away. Wait a bit, and see them grow.

What does this mean?

It means that if you are injecting upwards of 50mcg of IGF-1 you are growing your intestines. Yes you are also growing muscle and you may be getting leaner in the process. Your waistline looks trimmer. Nice. A few months down the line, your new intestinal cells will be of their full adult size and you will have acquired the perma-bloat look. Guaranteed. Maybe not Coleman-size perma-gut, but SOME perma-gut and it will keep growing. Guaranteed. Just as your new muscle cells can keep growing and growing IF you pin IGF-1 in a way to maximize new muscle cell creation.

HOW?

Heavy resistance exercise strongly upregulates the IGF-1 receptors on the stressed muscle. That means that after your workout, the muscles you trained are at their BEST STATE for receiving IGF-1 and growing many new cells. That's when you pin. This upregulation of IGF-1 receptor during exercise is short-lived. The science is not readily available so I am unable to quote a paper, but within 60 minutes of the last set, the receptors are back at baseline. This means, PIN IMMEDIATELY POSTWORKOUT and you will get your new muscle cells. PIN A LESSER AMOUNT and you will get only new MUSCLE cells out of your IGF-1. Pin more and you will grow other things, including stuff you wish you didn't grow.

What else?

All the talk about IGF-1's half-life is UTTER BULLSHIT. It is technicality without any real-world applicability. Yes rhIGF-1 has a "short half-life". But what does it mean? It means that it is either taken up by a cell receptor or bound up by a binding protein in short order. Does it mean that 20 minutes after the IGF-1 is pinned you should pin more because "blood levels are low"? Not by any means. Once it's activated a cell receptor, that's where it initiates a cellular response that will take about 72 hours to be complete and which will consume lots of energy. So the half-life of 20 minutes means NOTHING BECAUSE THE EFFECTS STILL LAST 72 HOURS ALL THE SAME.

What about Long R3 IGF-1?

Yes technically it has a longer half-life. Why? Because it either gets rapidly taken up by a cell receptor or... Just floats around. Until it can find a receptor or is destroyed by the immune system or some other metabolizing mechanism. BUT THIS MEANS ***NOTHING***!!! Why does it mean nothing? BECAUSE once it attaches to a cell receptor, it initiates a cellular response that will take about 72 hours to be complete. THIS CELLULAR RESPONSE IS ALL THAT INTERESTS US. Not "blood levels", that's utter bullshit. As a matter of fact, the one thing YOU DO NOT WANT IS FOR BLOOD LEVELS OF IGF-1 TO BE ELEVATED. Because that means you are growing everywhere and this means first and foremost your guts. Sure it feels like it's working while you're on. Just you wait 9 months and see that you look like Craig Kovacs. Bravo, you now have the biggest intestines in the world.

Half-life means nothing. Localized vs systemic = bad argument. You want localized effects. Period. You get them by pinning immediately postworkout. Period. End of argument.

OMFG I am so tired of all the misinformation floating around on IGF-1. Look at the length of this post. Did you read all of it? You should, you know."

Last edited by breakthrough; 03-30-2010 at 09:28 AM.
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Old 03-29-2010, 04:22 PM
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Hmmmmm so I cant really take the shit to my gym with me unless i carry a icechest in my car or something to keep it cold, so what is the time frame from gym to house to give yourself an inject? I live about 15 minutes away from my gym so is that too long to wait for the injects? Just wondering?
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Old 03-29-2010, 04:26 PM
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Originally Posted by Phosman40 View Post
Hmmmmm so I cant really take the shit to my gym with me unless i carry a icechest in my car or something to keep it cold, so what is the time frame from gym to house to give yourself an inject? I live about 15 minutes away from my gym so is that too long to wait for the injects? Just wondering?
I've been reading about this shit all day and last night too and I remember seeing this discussed in a post and I would think 15-20 minutes should be just fine after the last weight lifted.
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Old 03-29-2010, 04:28 PM
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One important thing to remember about this stuff is that you can go hypoglycemic, so make sure to get your post workout carb-up. The other very important thing I can think of from what I've read is proper reconstitution. I have found a few sources for this stuff and some of them sell it already reconstituted in AA (acetic acid [distilled vinegar]) which has to be further diluted with bacteriostatic water as needed for injections. You would want at least a 4:1 ratio of BW:AA so that no muscle cell death occurs upon injection. Personally I think I'll be getting it in lyopholized form (freeze dried/powder) and reconstituting it myself although, I've read it can remain stable in AA for a year in the freezer.

Last edited by breakthrough; 03-29-2010 at 04:36 PM.
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Old 03-29-2010, 04:47 PM
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Uh oh! BT is gettin fired up!...lol
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Old 03-29-2010, 04:58 PM
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Originally Posted by Chal View Post
Uh oh! BT is gettin fired up!...lol
Yeah lol, the itch is back! Let me throw this out there too.....there will be IGF-1 LR3 advertised as "Receptor" grade and "Media" grade. From what I've read, it's the samee shit just labeled differently to pull more profits from receptor grade labeled kits. I've read that Gropep is the shit and I found a high rated source that has it reconstituted in AA for a very reasonable price with cheap shipping and no minimum order .
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Old 03-29-2010, 05:05 PM
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Well mine is freeze dried and I have the AA and Bac water already but was just wondering on the length of time from gym to home or should I just take my ice chest with me and do it in the car. Not very sterile invronment if you ask me. LOL Well thanks then
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Old 03-29-2010, 05:34 PM
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Originally Posted by Phosman40 View Post
Well mine is freeze dried and I have the AA and Bac water already but was just wondering on the length of time from gym to home or should I just take my ice chest with me and do it in the car. Not very sterile invronment if you ask me. LOL Well thanks then
If you can swing it, I would take it to the gym. I don't think sterility will be much of an issue being that the needle will be capped and inside of a ziplock sandwhich baggie and you'll have your alcohol prep pads with you (I'm assuming). The only thing is how you'll load the pins. I still haven't actually sat down and thought it out myself yet. I have to do some more research on it because I would not want to keep letting the 2ml of IGF-1 LR3 & AA solution defrost to load individual syringes and then add BW so..... I've actually read also that the common consensus of it having to be kept in AA to keep it from degrading may not be accurate. I may buy .01mg (100mcg) vials instead and reconstitute 100mcg at a time using only BW.
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Old 03-29-2010, 07:01 PM
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Emailed the source I think I'm going to use and I'm waiting on a response. I asked about the ready made version that's already reconstituted in AA and whether or not being out of the freezer during transport will compromise the integrity of the compound. I also asked how long reconstituted IGF-1 LR3 will remain stable in the average freezer. I did read that when suspended in AA, LR3 IGF-1 is stable at room temperature and all the reports of premixed products being a high risk purchase is because of what it used to be suspended in. Before I make a move, I'd like to hear from the distributor.

Last edited by breakthrough; 03-29-2010 at 07:36 PM.
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Old 03-29-2010, 09:14 PM
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Would this premise be valid in the following syllogism? Considering what I read in the post it strongly indicates that possibility.

If IGF is best injected post workout to target the up-regulated stressed muscles, and if a particular muscle group is worked each workout, then that particular muscle group could be targeted with selective use of igf. Therefore, non use of igf after a particular workout would allow igf muscle groups (those injected post workout with igf) to catch up to attain better symmetry with more developed muscles.
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Old 03-29-2010, 09:25 PM
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Originally Posted by alaski View Post
Would this premise be valid in the following syllogism? Considering what I read in the post it strongly indicates that possibility.

If IGF is best injected post workout to target the up-regulated stressed muscles, and if a particular muscle group is worked each workout, then that particular muscle group could be targeted with selective use of igf. Therefore, non use of igf after a particular workout would allow igf muscle groups (those injected post workout with igf) to catch up to attain better symmetry with more developed muscles.
My brain is very tired from researching so I had to read that 3 times lol. There does seem to be a lot of reports of spot growth, however, I don't think it is going to be serious in the LR3 because it makes it into circulation rather than being being rendered inactive by binding proteins. I would have to say based on all the reading though, that it would still be worth using it that way spotting bilaterally.
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Old 03-29-2010, 09:43 PM
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Originally Posted by breakthrough View Post
My brain is very tired from researching so I had to read that 3 times lol. There does seem to be a lot of reports of spot growth, however, I don't think it is going to be serious in the LR3 because it makes it into circulation rather than being being rendered inactive by binding proteins. I would have to say based on all the reading though, that it would still be worth using it that way spotting bilaterally.
My thinking was "if" my ass is too big (my ass is not big but if it was) then after doing squats I don't use igf...lol.
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Old 03-29-2010, 09:50 PM
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Originally Posted by alaski View Post
My thinking was "if" my ass is too big (my ass is not big but if it was) then after doing squats I don't use igf...lol.
I'd say that's a good plan. My ass has a tendency to grow on me so, yea, I won't be doing any glute shots either lol.
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Old 03-29-2010, 10:45 PM
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Default This stuff is sounding better and better

Read this: TUBROVITAL
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Old 03-29-2010, 11:05 PM
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Default some info on storage of LR3 IGF-1

Storage
The stability of a liquid solution of LR3IGF-I was monitored for a period of two years at storage conditions of -20 C, +4 C, +22 C, and +37 C. The final concentration of LR3IGF-I was in acetic acid. At various time points, samples were taken and compared to a lyophilized control (stored at 4 C). Listed below are the stability results for each respective storage condition.
Storage Condition: -20 C (-4 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years
Storage Condition: +4 C (39.2 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years
Storage Condition: +22 C (71.6 F)
Biological Potency No Change up to 2 years
Immunological Activity No Change up to 2 years
Mobility of Protein No Change up to 2 years
Elution Profile by reversed phased HPLC No Change up to 2 years
Storage Condition: +37 C (98.6 F)
Biological Potency No Change up to 1 year
Immunological Activity No Change up to 1 year
Mobility of Protein No Change up to 1 year
Elution Profile by reversed phased HPLC No Change up to 1 year
In conclusion
There is no significant difference in the potency of LR3IGF-I associated with the storage of the liquid formulation when stored at this range of temperatures. There is no evidence for loss of biological activity at any of the tested temperatures when stored as a liquid product. As you can see IGF can be quite stable for even a year at room temp, but if you want to keep it around for a while stick it into the fridge. So IMO the best way to store LR3 that is suspended in BA is in the freezer. The BA wont allow it to freeze. And if you have it suspended in AA, store it in the fridge.
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Old 03-30-2010, 06:32 AM
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Originally Posted by breakthrough View Post
Read this: TUBROVITAL
Interesting. It says that when taken IM, IGF-1 LR3 does not enter the blood stream. Which would seem to say that it should be site injected...but then again if it did not enter the blood stream, how would it make your intestines grow? I'm a little confused there..
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Old 03-30-2010, 08:51 AM
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Originally Posted by Chal View Post
Interesting. It says that when taken IM, IGF-1 LR3 does not enter the blood stream. Which would seem to say that it should be site injected...but then again if it did not enter the blood stream, how would it make your intestines grow? I'm a little confused there..
Damn good observation Chal. I think some further investigation is in order.
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Old 03-30-2010, 09:08 AM
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I found this which is actually the missing first and last part of post #1 in this thread (which I mistakenly thought was Palumbo's words but appear to be the words of a researcher who has followed Palumbo's work) saying that LR3 does not get into the blood stream but still spreads systemically binding to the nearest receptors first (and pretty much answers all other questions too):

On July 20 I got into some pretty intense discussion on another board about IGF-1. I got so rattled with the misinformation that I decided to loose my 13 years of reading on IGF-1 onto that board. Here's the result.

If you want to use IGF for localization growth get some rhIGF-1. It binds to the wound only and does not go into the bloodstream. This helps repair the injection wound and makes new cells in that area only. While Long R3 IGF binds somewhat to the would then makes its way to the blood stream causing growth throughout the body..

This is false.

The difference between rhIGF-1 and Long R3 is that the Long R3 does not get bound by binding protein and thus is 100% active whereas you do lose a great % of whatever amount of rhIGF-1 you inject to IGFBP3.

While technically it is true that if you inject a large amount of the rhIGF-1 it will have almost only localized effect, it is so because the "excess" that does not bind to cells in the muscle in which it is injected is rapidly bound up by IGFBP3 and thus rendered mostly unusable by cells elsewhere. It would be much much better in such a case to inject a smaller amount and not have ANY excess that gets bound up by IGFBP's.

And while technically it is true that if you inject a large amount of Long R3 IGF-1 in a muscle, it will first bind to the nearest available receptor, and spread, binding to more and more receptors and not be bound up and neutralized by IGFBP's, meaning that it will travel all through your body and grow all kinds of tissue. This is called the systemic effect of IGF-1. Therein lies the only distinction in terms of BOTH half-life and localized/systemic effect between the Long and the human varieties.

Now here is some that came after what was written in post #1:

I was thinking about trying IGF, very interesting info here. Thanks Grunt for posting this info. A couple of other questions that maybe you can answer, if you don't mind. How does IGF interact with insulin, i.e. can it be pinned with insulin post workout? Also, what are your thoughts on taking IGF durring a cycle of HGH?

Great questions. I'll start with some background on the peptides from back before IGF-1 was commonly used. GH was the first peptide to be used in Bodybuilding. We pretty much know what GH does and doesn't do and all that, so I'll skip this part. Then came along insulin. It quickly became apparent that slin on its own doesn't do much for muscle. It does make you fat but not much bigger. With anabolic steroids and tons of food, it's better. Later it became extremely clear that Slin & GH was the winner combo, the most synergistic combination around.

What few people realize even today - and it's been what, nearly 20 years of insulin usage in BBing, is that the very reason why slin and GH are synergystic is that when levels of both are high, the liver turns the GH into IGF-1. That's right, when doing slin & GH, you are in fact using these because your body makes more IGF-1 with them. So it isn't the slin OR the GH nor actually the compounding of the effects of each, but rather good old IGF-1. Even the name Insulinlike Growth Factor, has been made such because of the origin of the compound in Insulin and Growth Hormone.

Now, the IGF-1 from slin & GH is not long R3 IGF-1, it's hIGF-1. It's different and possibly the effects are somewhat different than when using Long R3, especially with regards to IGF-1 losing effectiveness, which is likely much lesser with the liver-synthesized IGF-1 than with the Long R3. No studies proving this, it is theory at this point and such a study will possibly never be made, for many good reasons. One reason why hIGF-1 loses effectiveness less quickly is its half-life, or its very limited ability to run around the body and saturate all receptors everywhere. And here we join up with the EOD and E3D protocols which state that letting the body rest is extremely important to continued results. You get the same effect out of slin & gh because of IGFBP3 that mops up the IGF-1 within minutes of synthesis, which makes it impossible to saturate the receptors and lets them rest. Similar effect, completely different way of achieving it.

So slin & gh are synergistic. Then the next question: what about slin & IGF or Gh & IGF? IGF is synergistic with both. MOST of the effects of GH are mediated through IGF-1 but not ALL of them. Among the good effects of GH that IGF-1 does not exert is anabolism to ligaments, for example. This is just an example to show that there is a benefit to using GH & IGF-1 at the same time. There is evidence that ED dosing of LR3 reduces GH release in the body, so it makes plenty of sense to use both at the same time.

Slin & IGF is a different animal. Most of the benefits of insulin come from its ability to increase IGF-1. Unless you are diabetic, your body makes enough insulin. Eat more, it releases more insulin. More carbs? More slin. The limit to the body's ability to release slin isn't easily reached. Even feeding 10,000 cals ED your body can produce the slin to store that. Easily. This is not to say that exogenous insulin supplementation is not useful. I have seen an account that multiple daily doses of just 3iu produces a body-wide pump that lasts all day. Look, I'm not diabetic but I have never achieved this effect with my own natural insulin. So obviously there's something going on there.

Am I stating there is no use in pinning slin & IGF together? No. There is evidence that shows that pinning slin with IGF-1 increases the length of the effects of IGF-1. Especially the hypoglycemic effects, obviously, but this has pretty far-ranging and beneficial implications, among which saturating the lean cells with nutrients and having a low blood sugar level are not the least. Obviously they are both hypoglycemic compounds so carbs have to be adjusted up when adding IGF-1 to slin, or slin reduced. I prefer the second option, although I am at a loss as to the amount of slin you would have to remove for compensation with, say, 40mcg IGF-1.

Personally I have not done this. Both my grandfathers were diabetics, so I'm not playing with slin. Especially that I have a natural tendency to go hypoglycemic easily. IGF-1 though is simply GREAT for me.

What I did do, over 10 years ago, is use an extremely potent GH releaser named GHB and combined that with a few ounces of sugar, the idea being of course a cheap version of GH & Slin. Obviously it worked great over a few months and it did produce hyperplasia, as made very obvious by the muscle size I retained when taking a 2 year layoff from lifting because of a non-training related injury.

Dont take this as me being a **** but do you have some experience with IGF Grunt? If so what were your gains? And have you tried rhIGF? What kind of gains from those? I would guess with as much knowledge you have on this you'd have to have run it before.

I have run LR3 at 20, 30, 40 and 50mcg ED as well as variations of only postworkout pinning. I suggested EOD and gapped dosing way before lab research showed that this would be a better dosing protocol.

In my experience, IMMEDIATELY-POSTWORKOUT dosing is all-important to hyperplasia. SOME benefit is had by pinning preworkout and at other times, but the vey best resutls from pinning immediately postworkout. I have experimented with 5-minutes postworkout and 20-30 minutes postworkout and have found the 5-minutes postworkout dosing to be VASTLY superior to any other dosing protocol. I know it isn't the most practical for most of us, but I'm saying what I have seen on myself. Others report only slightly better results from going immediately postworkout as compared to, say, 20-30 minutes post.

Gains out of IGF-1 are difficult to account for. Firstly, it is much more a recomposition compound than a mass or fatloss compound. On anabolic steroids, the gains are "this many lbs of LBM". On clen/Thyroid, gains are "so many lbs of flab". On IGF-1 the gains are "some fatloss, some muscle gain/retention, and this many new cells that I will grow in the coming months".

But suffice it to say that my first experimentation protocol was 5 minutes postworkout in my biceps, delts and chest because my previous research had indicated that the postworkout window was limited, and because those were my lagging bodyparts. My biceps went from 17" to 17" in the first 2 weeks along with some fatloss and another " in the 2 months afterward, my DB curls going from 55 x 10 to 65 x 10. That was after 12 years of natural training, with genetic potential pretty maxed out. Chest and delt results I did not even attempt to quantify but the difference was clearly visible.

On another board there was a log where the guy was shooting only his biceps because he read that local effects were little and his bis were lagging. A couple months after his log was done I asked about his biceps and he said they had now taken the lead in his muscular development.

WOW this thread is awesome. I am 100% with you on the conservitave part, why put your health and life and for alot of of us here LOOKS in jepordy? On the other hand I must be the devils advocate, even though I feel a bit overwhelmed by some of these knowledgable bros...

Could this change with large doses of anabolic steroids? I could be wrong. Completely so, but with verry large amounts of certain anabolics your IGF raises drasticaly. Why would this not result in some for of perma gut?
I beleive GH can cause some organ growth correct? Maybe that has a different mechanism but it seams this only happens at verry high doses over verry long periods of time.
Why do we not see such organ growth with the use of extreme amounts of AAS over periods of years? And a more importantly, if you were to take large doses of AAS especialy those of the stronger breed do you think that the doses could increase, perhaps from increasing the rate of the receptors processing the IGF-1r3.

Also wouldn't it be verry usefull to use this chemical post cardio because of the blood pumping so drasticaly to the muscle sites, even pre or mid cardio work out?

I'm sorry if I'm being dense, I gotta ask the questions!!


Those are actually some very good questions. The answers are equally good.

There are two completely different ways in which IGF-1 is produced in the body. Even the IGF-1 molecule itself is slightly different in each case. The first, well known case, is where GH & Slin are used by the liver to make IGF-1 which is then released into the bloodstream. AAS has little to no bearing on this systemic, or "paracrine" IGF-1. It just circulates in the bloodstream and eventually finds an IGF-1 receptor on the outside surface of a cell and attaches to it, activating it.

The other pathway, the one that is rarely discussed, is the autocrine pathway. This is where a cell will produce its own IGF-1, different peptides than the systemic, for its own internal use. These are called IGF-1Ea and IGF-1Ec or MGF. They are produced inside the cell, and act on receptors within the cell and just outside of the cell, on the myoblasts. These peptides don't go anywhere. When they leave the cell, they stay close to the surface. This is the pathway that AAS will greatly upregulate.

So on one hand you have the systemic with its effects on the surface receptor and you have the autocrine with its effects on the internal receptor, on the myoblasts and also perhaps on the surface receptor. So obviously when you know this it becomes obvious that the IGF-1 from AAS - the autocrine - will never give you the GH gut because the IGF-1 that it makes your cells produce never leaves the cell itself, it doesn't circulate around to go attach to an intestinal wall receptor.

The pathway through which GH causes organ growth *IS* systemic IGF-1. Most of the effects of GH are actually effects of IGF-1. GH is simply not very active on many cells but it is much converted by the liver into IGF-1 and this is what mediates the effects of GH. As I posted above, there ARE some effects of GH that are not mediated through IGF-1 but most of them are.

As far as upregulating the surface receptors through AAS usage, I have seen no evidence that points that way, but that is not entirely impossible. Improbable, but not impossible.

As far as pinning post-cardio, I don't see it. In my opinion, for bodybuilders IGF-1 has two main purposes: firstly hyperplasia, its main use, and secondly general tissue repair, meaning healing and preventing injury. Ligaments aren't repaired by IGF-1 but they're a rare exception. It is too expensive and too good at better things IMO to be wasted on a simple pump.

How would one transport this to the gym for post wo injection? What's the best way to maintain integrity, avoid heat and not losse any?

Suggestions?


Diluted in AA, it is stable for a year at 98 degrees F. Of course, the insides of your car in the midst of a sunny summer day will be much hotter than that. Not the inside of your locker though.

What I always do is to load up a syringe with just the needed amount of IGF & AA, then use a small amount of aluminum foil to make a spacer between the end of the plunger and the cylinder to avoid discharging the syringe in transit, and put this and a couple alcohol pads and my BW inside a sunglass case in my gym bag.

I grab my bag after my workout, go change in the shower or toilet and pin at the same time. Then I get my shake.

IGF-1 is legal, so it shouldn't give you that much trouble. I am aware that some U.S. states have "drug paraphernalia" laws that get you charged for just having a syringe on you. My suggestion: move. I live in Canada so my legal knowledge for U.S. citizens is very limited. Still, I don't see how someone is going to find out what I do in my toilet stall...

Never was a problem for me. I know a guy who tried in his car and was seen a few times, and got in some crazy situations with that. No police or anything, just zany adventures of a stressed guy.

Great info Grunt....I always like reading your stuff. I am in the middle of a 16week anabolic steroids cycle, and I started it using IGF, by the end of this 16 weeker I should have not only larger cells from the AAS but new cells from the IGF that are now larger cause of the AAS correct.

Indeed my friend. On top of having more actual muscle cells, the IGF-1 will also fuse myoblasts with your existing cells and donate their nucleii which are in fact myonucleii.

A muscle's protein-repair engine is the myonucleii. The more of them in a cell, the bigger the cell and the greater the ability to regenerate protein. This explains the permanent gains from IGF-1 in that the number of myonucleii does not easily decrease, which gives a cell a new minimum size. Unless of course a person undergoes starvation, but that's not the case around these parts. When we take AAS, it's the myonucleii that get stimulated into overdrive. This is how IGF-1 can make you a good responder to AAS again after numerous cycles when you feel you can't grow much anymore.

One limiting factor for the myoblast fusion effect is of course the number of available myoblasts. The more of them you have, the more easily they will fuse with the muscle cells and donate their myonucleii. Below a certain treshold, they will simply refuse to fuse. This is easily prevented by the addition of MGF, which is only active in one formulation of Pegylated MGF. MGF proliferates the myoblasts. Adding MGF to the IGF cycle makes tons of sense: you keep the myoblast numbers high and fusion keeps going strong.

i know nuttin about igf so dont take this wrong im just curious, was this info from research or someones theroy. the only reason i ask is cuzz you put a limit on the mcgs before it went to intestins. everyone is different where did the # come from? thanks for your time.

It's all Grunt76's work. 13 years of research and human trials.

You are right, the number is a guesstimate and I have removed it from this version of my thread for the reason that it was getting misunderstood as an absolute rather than an indicator. From talking with other users, 40mcg is a dose at which, when injected immediately postworkout, good long-term gains are experienced with slowly diminishing effect.

The ideal dose would be the one that you can use forever. Remember, if you inject just the right amount immediately postworkout, there will be no spillover of the IGF-1 into other receptors and so these (local) receptors will have plenty of time to re-upregulate and the myoblasts to re-proliferate before next injection time, and so for every bodypart.

Sadly I must report that I have not yet found that "perfect dose" so 40mcg is a good place to go, where you get your results, no major gut effect and only slow desentitization.

No matter how you split it, the "perfect dose" would be variable depending on muscle worked, intensity of workout and about a zillion other factors, making it just a theoretical thing.

Question, and it may not belong in this thread. I've been catching up on my reading of IGF as I am interested in using it in my next post cycle therapy.

Do you still suggest the EOD protocol for post cycle therapy or ED? I typically have 5 lifting days a week.

Also about localized injections. Let's say you work out biceps and lats one day. And let's say you're doing 50mcg of IGF, should you split the dosage between both bi's and your lats? Making for 4 doses of 12.5mcg?

I apologize if that's a dumb question but I haven't seen that explained in all the threads I've been reading. It would make sense to me to split it up like that, but I could be wrong.

And lastly, just to reinforce what my reading has burned into my head. IM shots are vastly superior to sub-q... correct?


Any answers would be helpful while I continue educating myself on this supplement

-Sendo

Just pick either your biceps or your lats for pinning, 2 doses of 20-25mcg is good. The following week, you can pick the other bodypart.

For PCT, a product like Oratropin-1 might be the best bet. It is systemic and time-released, and is the only form of IGF-1 that can get to the pituitary itself, which makes it perfect for full recovery from the longest, harshest cycles. Otherwise just keep on keeping on with standard IGF-1 protocols.

Yes IM shots are vastly superior to SQ.

Grunt, great post. I have a couple of questions.

What would your body naturally produce of IGF on any given day if any? What would be the range? Would it be 5mcg. I am just trying to gain a percpective on how much we are injecting above our natural production.


I have read that Dave Palumbo, the pro bodybuilder with 3 years of med school asserts that the amount of paracrine IGF-1 produced by a human body is in the 1mcg range. There should be broad fluctuations about this measurement, which surely must be a guesstimate.

Thanks, so even if its 2mcg per day were injecting apprx. 20xs normal production.

Assuming you have time, do you think going lower doses for longer periods would be a safer way to gaurd against intestinal growth and still get the positive results desired? Say 10-20mcg range?


Yes, there is a protocol developed by Palumbo wich does this.

I prefer the idea of doing 40mcg E3D though.

Both might be equally good and safe, for all I know.

from the studies i have read scientists postulate that myostatin and igf-1 present in cardiac muscle operate on completely separate pathway in comparison to skeletal muscle.

in other words, igf-1 and myostatin inhibition will not have the same effect on cardiac muscle as it does on skeletal muscle.

can you confirm this grunt? i havent seen any difinitive studies, and dont want to give out brotelligence


I cannot confirm this, although I agree there is no evidence of any heart-enlarging effects. For example, Long R3 IGF-1 is used for kids with deficiencies and no heart size monitoring is ever done but these are growing children, so their hearts probably do need to grow anyways. Pubmed is at your disposal if you want to look into that aspect of it. I concentrated my studies on enhancing the local effect and lessening the systemic.

So the igf-1 is more effective than the lr3 version?

This whole thread is about Long R3 IGF-1. And no, hIGF-1 isn't more effective.

Virgin Cycle.... HGH alone? Igf-Lr3 alone? Mgf alone? HGH/IGFlr3? IGF/MGF? HGH/MGF????
They are all low-side-effect options bro, any of these is good.

Some people will say that you should start with anabolic steroids (even the semi-legal ones) before the peptides, but I like peptides for a first-timer, because they are low on sides and their effects are more subtle.


Look Grunt, I know some pros personally and if you ask them they will tell you that IGF-1 doesn't give you the guts, it's all the insulin.

Well if you read a bit more in this thread and got some science in you, you would know that GH & insulin produce IGF-1 which is released in the blood. The pros pretty much all take GH with their slin. So there.

And I'm not saying that 100mcg ED guarantees that you will get gut growth. There is obviously no way to ascertain that. I have gotten PM's from guys doing 80mcg - 120mcg ED and getting gut so take that the way you need to. One thing is for sure: you are much more likely to get it if you dose ED than at the same dose E3D.

Great post Grunt- always like readin your stuff
Thanks bro. The compliment means a lot.

Last edited by breakthrough; 03-30-2010 at 09:31 AM.
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Old 03-30-2010, 10:30 AM
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There is lot of reading on the subject with differing opinions (some out dated) as to the igf protocol. Have you found consensus (besides post workout) for dosage, site injection, and frequency recommendations? Moreover, I am somewhat confused about reconstitution and storage after reconstitution. I understand acidic acid and biostatic water are the components for reconstituting igf but since most igf come in 1000mcg vials, that would leave considerable amount left over after first dosage.
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Wow! Thats a ton of good info. So it's the dosage and receptor affinity that determines where and how far the effects are. I don't remember this stuff from 8 yrs ago or so when I was a Meso member. Either I missed out on it or it just went over my head back then. I can see why you are liking this stuff. The neat thing is you can really pinpoint (ha pun intented) where you want results. Pretty fkg cool! I have heard good things from others about it too. I'll definitely be gathering knowledge for the future bro. Great thread for me.. thanks.
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Old 03-30-2010, 11:53 AM
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There is lot of reading on the subject with differing opinions (some out dated) as to the igf protocol. Have you found consensus (besides post workout) for dosage, site injection, and frequency recommendations? Moreover, I am somewhat confused about reconstitution and storage after reconstitution. I understand acidic acid and biostatic water are the components for reconstituting igf but since most igf come in 1000mcg vials, that would leave considerable amount left over after first dosage.
I agree but you can kind of tell who is regurgitating hear say and who actually knows what they are talking about and I've read all the differing opinions out there it seems and I'm going to follow what's in this thread. I would stick to 40mcg pwo and only use on workout days working out EOD. As far as storage, it can be kept in AA for up to 2 years at room temp but I would personally keep it in the fridge or freezer and only add BW right before the injection at a minimum 4:1 ratio BW:AA. Basically you would add 2ml AA to 1000mcg IGF-1 LR3 (or get the premixed Gropep) and then in a 1ml slin pin 8 ticks (.08ml) would be = to 40mcg. You could preload all your slin pins with .08ml and freeze (or fridge) them and then add the BW right before injecting. If you are reconstituting yourself, make sure to let the AA run down the side of the vial slowly into the powder. Do not spray it on to the powder. Let it dissolve without shaking it and that's it. Re-read through this thread as most of it is explained. Hope this helped.
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Old 03-30-2010, 01:36 PM
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Ok, I just heard back from the supplier of the Gropep Reconstituted stuff (which is supposed to be the most reliable out there) and it is actually suspended in Benzyl Alcohol (BA) and is said to be stable for 2 years in the freezer. I just ordered a 1mg vial so.....I'm siked!
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Ok, I just heard back from the supplier of the Gropep Reconstituted stuff (which is supposed to be the most reliable out there) and it is actually suspended in Benzyl Alcohol (BA) and is said to be stable for 2 years in the freezer. I just ordered a 1mg vial so.....I'm siked!
So what's that figure to?...about 20-25 bilateral spots as you call them?
I noticed also that its in BA instead of AA. Why the change? Is it because the vinegar is too acidic? And do you still have to dillute it in the BA? Sorry for all questions but now you got me interested...lol
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Old 03-30-2010, 04:25 PM
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Ok, I just heard back from the supplier of the Gropep Reconstituted stuff (which is supposed to be the most reliable out there) and it is actually suspended in Benzyl Alcohol (BA) and is said to be stable for 2 years in the freezer. I just ordered a 1mg vial so.....I'm siked!
I've seen that at one of the research chem sites and they are calling it "1mg Australian Long-R3-IGF-1(Suspended in Benzyl Alcohol)." Is this type suppose to be the best for longevity? Do you know if the potency and viability is equal to Lyophilized igf? I noticed that the Lyophilized is little bit less expensive.
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Old 03-30-2010, 05:03 PM
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I've seen that at one of the research chem sites and they are calling it "1mg Australian Long-R3-IGF-1(Suspended in Benzyl Alcohol)." Is this type suppose to be the best for longevity? Do you know if the potency and viability is equal to Lyophilized igf? I noticed that the Lyophilized is little bit less expensive.
This stuff is supposed to be better than lyophilized and anything from any other brand for that matter. A couple guys on Outlaw Muscle said it's much, much better than Gensci stuff and one guy said people are asking him if he's on steroids when all he's taking is the Gropep. Longevity wise, a vial is said to last 2 years in the freezer. The lyophilized IGF from this supplier was only $30 less than the Gropep Recon and that's worth it to me considering the reputation of this brand name and the ease of preparation.

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